Primary ovarian failure

E4_OVARFAIL

primary ovarian insufficiency: Absent or premature cessation of ovarian function due to a pathologic process originating within the ovaries.

Endpoint definition

FinnGen phenotype data

429209 individuals

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Apply sex-specific rule

Sex only females

239906

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Check conditions None

239906

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 E28.3
Hospital discharge: ICD-9 2563
Hospital discharge: ICD-8 2561
Cause of death: ICD-10 E28.3
Cause of death: ICD-9 2563
Cause of death: ICD-8 2561
KELA reimbursements: KELA codes ANY
KELA reimbursements: ICD-10 E28.3

3 out of 7 registries used, show all original rules.

580

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Check minimum number of events None

580

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Include endpoints None

580

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Remove individuals based on genotype QC

542

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E4_OVARFAIL

Control definitions

Control exclude E4_ENDOGLAND

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 E28
Name in latin Insufficientia ovariorum primaria

Summary Statistics

Key figures

All Female Male
Number of individuals 542 542 -
Unadjusted prevalence (%) 0.13 0.24 -
Mean age at first event (years) 35.78 35.78 -

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.06 [0.63, 6.78] 2.3e-1 22
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: E4_OVARFAIL – Primary ovarian failure
GWS hits: 1

Survival analyses between endpoints

Plot

before Primary ovarian failure
after Primary ovarian failure

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Drugs most likely to be purchased after Primary ovarian failure

Endpoint not on priority list, no data to show.