Adrenocortical insufficiency

E4_ADDISON

No definition available.

Endpoint definition

FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 E27.1, E27.2, E27.3#, E27.4
Hospital discharge: ICD-9 2554
Hospital discharge: ICD-8 2551
Cause of death: ICD-10 E27.1, E27.2, E27.3#, E27.4
Cause of death: ICD-9 2554
Cause of death: ICD-8 2551
KELA reimbursements: KELA codes 105

3 out of 7 registries used, show all original rules.

1035

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Check minimum number of events None

1035

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Include endpoints None

1035

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Remove individuals based on genotype QC

1002

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E4_ADDISON

Control definitions

Control exclude E4_ENDOGLAND

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 1002 669 333
Unadjusted prevalence (%) 0.24 0.29 0.18
Mean age at first event (years) 51.03 49.49 54.14

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.09 4.35 [2.31, 8.17] 4.9e-6 128
15 years 0.02 2.08 [1.08, 4.02] 2.9e-2 41
5 years 0.01 6.73 [3.61, 12.53] 1.9e-9 40
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: E4_ADDISON – Adrenocortical insufficiency
GWS hits: 1

Survival analyses between endpoints

Plot

before Adrenocortical insufficiency
after Adrenocortical insufficiency

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Adrenocortical insufficiency

Endpoint not on priority list, no data to show.