Drug-induced adrenocortical insufficiency

Endpoint Browser PheWeb

DRUGADVERS_ADRENOCORTICAL_INSUFFICIENCY

No definition available.

Endpoint definition

↥

FinnGen phenotype data

429209 individuals

diagram downward connector

Apply sex-specific rule None

429209

diagram downward connector

Check conditions None

429209

diagram downward connector

Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 E27.3#

1 out of 7 registries used, show all original rules.

455

diagram downward connector

Check minimum number of events None

455

diagram downward connector

Include endpoints None

455

diagram downward connector

diagram downward connector

Remove individuals based on genotype QC

441

diagram downward connector

DRUGADVERS_ADRENOCORTICAL_INSUFFICIENCY

Control definitions

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy C

First used in FinnGen datafreeze DF5

NAME	DRUGADVERS_ADRENOCORTICAL_INSUFFICIENCY
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	E273
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Show upset plot detailing case counts by codes

Or the full data table

Similar endpoints

↥

List of similar endpoints to Drug-induced adrenocortical insufficiency based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

↥

Key figures

	All	Female	Male
Number of individuals	441	308	133
Unadjusted prevalence (%)	0.11	0.13	0.07
Mean age at first event (years)	55.92	53.73	60.99

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.13	6.54 [2.07, 20.61]	1.4e-3	31
15 years	-	-	-	-
5 years	-	-	-	-
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

↥

Index endpoint: DRUGADVERS_ADRENOCORTICAL_INSUFFICIENCY – Drug-induced adrenocortical insufficiency
GWS hits:

Survival analyses between endpoints

↥

Plot

before Drug-induced adrenocortical insufficiency
after Drug-induced adrenocortical insufficiency

Loading survival analyses plot

Table

Loading survival analyses table

Drugs most likely to be purchased after Drug-induced adrenocortical insufficiency

↥

Endpoint not on priority list, no data to show.