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Asthma-related infections

DOID EFO MESH SNOMED Endpoint Browser PheWeb

ASTHMA_INFECTIONS

asthma: A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors resulting in recurring periods of wheezing (a whistling sound while breathing), chest tightness, shortness of breath, mucus production and coughing. The symptoms appear due to a variety of triggers such as allergens, irritants, respiratory infections, weather changes, exercise, stress, reflux disease, medications, foods and emotional anxiety.

Endpoint definition

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FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions

J10_ASTHMA

48366

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Check pre-conditions, main-only, mode, registry filters None

0 out of 7 registries used, show all original rules.

0

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Check minimum number of events None

0

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Include endpoints

25153

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Remove individuals based on genotype QC

24275

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ASTHMA_INFECTIONS

Control definitions

Control exclude ASTHMA_HOSPITAL_INFECTIONS
Control conditions not J10_ASTHMA

Extra metadata

First used in FinnGen datafreeze DF2

No data for upset plot.

No data for upset table.

Similar endpoints

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Summary Statistics

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Key figures

All Female Male
Number of individuals 24275 13764 10511
Unadjusted prevalence (%) 5.89 5.98 5.78
Mean age at first event (years) 44.06 43.07 45.34

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.07 3.56 [3.03, 4.19] 2.5e-53 4006
15 years 0.01 1.95 [1.73, 2.20] 2.5e-27 1486
5 years 0.00 3.55 [3.19, 3.94] <1e-100 1084
1 year 0.00 12.94 [11.44, 14.63] <1e-100 856

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: ASTHMA_INFECTIONS – Asthma-related infections
GWS hits: 26

Survival analyses between endpoints

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Plot

before Asthma-related infections
after Asthma-related infections

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Asthma-related infections

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Endpoint not on priority list, no data to show.