Chronic lower respiratory diseases


lung disease: A disease involving the lung.

Endpoint definition

FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None


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Check conditions None


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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 J40-J47
Cause of death: ICD-10 J40-J47

2 out of 7 registries used, show all original rules.


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Check minimum number of events None


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Remove individuals based on genotype QC


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Control definitions

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 73877 39600 34277
Unadjusted prevalence (%) 17.93 17.20 18.86
Mean age at first event (years) 47.10 42.80 52.07


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.05 2.78 [2.54, 3.04] <1e-100 13368
15 years 0.01 1.87 [1.73, 2.01] 2.1e-59 5117
5 years 0.01 3.76 [3.52, 4.02] <1e-100 3629
1 year 0.00 11.47 [10.45, 12.60] <1e-100 2275

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: J10_LOWCHRON – Chronic lower respiratory diseases
GWS hits: 72

Survival analyses between endpoints


before Chronic lower respiratory diseases
after Chronic lower respiratory diseases

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Drugs most likely to be purchased after Chronic lower respiratory diseases

Endpoint not on priority list, no data to show.