Alzheimer’s disease (Early onset) (more control exclusions)

Endpoint Browser PheWeb

AD_EO_EXMORE

No definition available.

Endpoint definition

↥

FinnGen phenotype data

individuals

Apply sex-specific rule None

Check conditions None

Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 F00.0*, F00.00*, F00.00*G30.0, G30.0, G30.0+F00.00

Cause of death: ICD-10 F00.0*, F00.00*, F00.00*G30.0, G30.0, G30.0+F00.00

2 out of 7 registries used, show all original rules.

Check minimum number of events None

Include endpoints None

Remove individuals based on genotype QC

1451

AD_EO_EXMORE

Control definitions

Control exclude G6_AD_WIDE, F5_DEMENTIA, F5_DEMENTIA_U, F5_PSYCH, NEURODIS, MEMLOSS, TRAUMBRAIN_NONCONCUS

Extra metadata

First used in FinnGen datafreeze DF2

NAME	AD_EO_EXMORE
CONTROL_EXCLUDE	G6_AD_WIDE\|F5_DEMENTIA\|F5_DEMENTIA_U\|F5_PSYCH\|NEURODIS\|MEMLOSS\|TRAUMBRAIN_NONCONCUS
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	F000\|G300
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	F000\|G300
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

No upset plot: script not run.

No upset table: script not run.

Similar endpoints

↥

List of similar endpoints to Alzheimer’s disease (Early onset) (more control exclusions) based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Alzheimer’s disease (Early onset)

Show all endpoint correlations

Summary Statistics

↥

Key figures

	All	Female	Male
Number of individuals	1451	662	789
Unadjusted prevalence (%)	0.35	0.29	0.43
Mean age at first event (years)	74.62	73.04	75.94

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.30	16.31 [14.22, 18.69]	<1e-100	977
15 years	0.03	4.33 [3.72, 5.03]	1.1e-79	251
5 years	-	-	-	-
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

↥

Index endpoint: AD_EO_EXMORE – Alzheimer’s disease (Early onset) (more control exclusions)
GWS hits: 1

Survival analyses between endpoints

↥

Plot

before Alzheimer’s disease (Early onset) (more control exclusions)
after Alzheimer’s disease (Early onset) (more control exclusions)

Loading survival analyses plot

Table

Loading survival analyses table

Drugs most likely to be purchased after Alzheimer’s disease (Early onset) (more control exclusions)

↥

Endpoint not on priority list, no data to show.

≡ Risteys

R10

R9

R8

R7

R6

R5

R4

R3