Vocal cord dysfunction

VOCALCORDDYS

human african trypanosomiasis: A parasitic disorder caused by protozoa of the Trypanosoma brucei species. It is transmitted by flies and is endemic in various regions of Sub-Saharan Africa. Signs and symptoms include fever, joint pain, headache, and significant swelling of the lymph nodes. If left untreated, the parasitic infection causes anemia, heart, kidney, and endocrine failure, and neurologic damage. Subsequently patients develop confusion, disruption of the sleep cycle, and mental deterioration. The infection may lead to coma and death.

Endpoint definition

FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 J38
Cause of death: ICD-10 J38

2 out of 7 registries used, show all original rules.

5811

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Check minimum number of events None

5811

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Include endpoints None

5811

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Remove individuals based on genotype QC

5612

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VOCALCORDDYS

Control definitions

Control exclude ASTHMA_COMORB

Extra metadata

First used in FinnGen datafreeze DF9
Parent code in ICD-10 J38

Summary Statistics

Key figures

All Female Male
Number of individuals 5612 3440 2172
Unadjusted prevalence (%) 1.36 1.49 1.20
Mean age at first event (years) 53.16 50.34 57.64

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.07 3.48 [2.57, 4.72] 8.2e-16 617
15 years 0.01 1.70 [1.32, 2.19] 4.7e-5 215
5 years 0.01 4.12 [3.29, 5.16] 1.1e-34 186
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: VOCALCORDDYS – Vocal cord dysfunction
GWS hits: 2

Survival analyses between endpoints

Plot

before Vocal cord dysfunction
after Vocal cord dysfunction

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Vocal cord dysfunction

Endpoint not on priority list, no data to show.