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Diseases of vocal cords and larynx+other diseases of upper respiratory tract, no elsewhere classified

DOID EFO MESH SNOMED Endpoint Browser PheWeb

J10_VOCALLARYNX

laryngeal disease: A non-neoplastic or neoplastic disorder that affects the larynx. Representative examples include laryngitis, vocal cord polyp, squamous papilloma, and carcinoma. [database_cross_reference: NCIT:P378]

Endpoint definition

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FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 J34, J38, J39
Hospital discharge: ICD-9 478
Hospital discharge: ICD-8 508
Hospital discharge: excluded ICD-8 50803
Cause of death: ICD-10 J34, J38, J39
Cause of death: ICD-9 478
Cause of death: ICD-8 508
Cause of death: excluded ICD-8 50803

2 out of 7 registries used, show all original rules.

22379

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Check minimum number of events None

22379

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Include endpoints None

22379

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Remove individuals based on genotype QC

21556

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J10_VOCALLARYNX

Control definitions

Control exclude J10_UPPERDIS

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 21556 10843 10713
Unadjusted prevalence (%) 5.23 4.71 5.89
Mean age at first event (years) 47.97 46.48 49.48

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.11 [1.71, 2.60] 2.1e-12 1673
15 years 0.01 1.38 [1.15, 1.66] 5.9e-4 672
5 years 0.00 2.57 [2.19, 3.01] 1.5e-30 367
1 year 0.00 7.41 [6.13, 8.94] 4.0e-96 203

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: J10_VOCALLARYNX – Diseases of vocal cords and larynx+other diseases of upper respiratory tract, no elsewhere classified
GWS hits: 1

Survival analyses between endpoints

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Plot

before Diseases of vocal cords and larynx+other diseases of upper respiratory tract, no elsewhere classified
after Diseases of vocal cords and larynx+other diseases of upper respiratory tract, no elsewhere classified

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Drugs most likely to be purchased after Diseases of vocal cords and larynx+other diseases of upper respiratory tract, no elsewhere classified

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Endpoint not on priority list, no data to show.