Vitamin deficiency

VIT_DEF

ascorbic acid deficiency: A condition due to a dietary deficiency of ascorbic acid (vitamin C), characterized by malaise, lethargy, and weakness. As the disease progresses, joints, muscles, and subcutaneous tissues may become the sites of hemorrhage. Ascorbic acid deficiency frequently develops into scurvy in young children fed unsupplemented cow's milk exclusively during their first year. It develops also commonly in chronic alcoholism. (Cecil Textbook of Medicine, 19th ed, p1177)

Endpoint definition

FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters None

0 out of 7 registries used, show all original rules.

0

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Check minimum number of events None

0

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Remove individuals based on genotype QC

1469

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VIT_DEF

Control definitions

Control exclude E4_NUTRIDEF

Extra metadata

First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 1469 851 618
Unadjusted prevalence (%) 0.36 0.37 0.34
Mean age at first event (years) 53.86 49.92 59.29

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.10 4.69 [3.22, 6.81] 6.2e-16 302
15 years 0.02 2.24 [1.52, 3.29] 4.7e-5 126
5 years 0.01 4.32 [2.98, 6.28] 1.4e-14 107
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: VIT_DEF – Vitamin deficiency
GWS hits:

Survival analyses between endpoints

Plot

before Vitamin deficiency
after Vitamin deficiency

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Drugs most likely to be purchased after Vitamin deficiency

Endpoint not on priority list, no data to show.