Vitamin D deficiency

E4_VIT_D_DEF

ascorbic acid deficiency: A condition due to a dietary deficiency of ascorbic acid (vitamin C), characterized by malaise, lethargy, and weakness. As the disease progresses, joints, muscles, and subcutaneous tissues may become the sites of hemorrhage. Ascorbic acid deficiency frequently develops into scurvy in young children fed unsupplemented cow's milk exclusively during their first year. It develops also commonly in chronic alcoholism. (Cecil Textbook of Medicine, 19th ed, p1177)

Endpoint definition

FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 E55
Hospital discharge: ICD-9 268
Hospital discharge: ICD-8 265
Cause of death: ICD-10 E55
Cause of death: ICD-9 268
Cause of death: ICD-8 265

2 out of 7 registries used, show all original rules.

518

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Check minimum number of events None

518

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Include endpoints None

518

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Remove individuals based on genotype QC

482

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E4_VIT_D_DEF

Control definitions

Control exclude E4_NUTRIDEF

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 E50-E64
Name in latin Deficientia vitamini D

Summary Statistics

Key figures

All Female Male
Number of individuals 482 314 168
Unadjusted prevalence (%) 0.12 0.14 0.09
Mean age at first event (years) 44.96 44.08 46.62

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.05 2.30 [0.63, 8.38] 2.1e-1 45
15 years 0.01 1.72 [0.63, 4.70] 2.9e-1 17
5 years 0.00 3.53 [1.51, 8.25] 3.6e-3 17
1 year 0.00 8.05 [2.90, 22.34] 6.2e-5 10

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: E4_VIT_D_DEF – Vitamin D deficiency
GWS hits: 1

Survival analyses between endpoints

Plot

before Vitamin D deficiency
after Vitamin D deficiency

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Drugs most likely to be purchased after Vitamin D deficiency

Endpoint not on priority list, no data to show.