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Tuberculosis

TUBERCULOSIS

obsolete_tuberculosis: ['A chronic, recurrent infection caused by the bacterium Mycobacterium tuberculosis. Tuberculosis (TB) may affect almost any tissue or organ of the body with the lungs being the most common site of infection. The clinical stages of TB are primary or initial infection, latent or dormant infection, and recrudescent or adult-type TB. Ninety to 95% of primary TB infections may go unrecognized. Histopathologically, tissue lesions consist of granulomas which usually undergo central caseation necrosis. Local symptoms of TB vary according to the part affected; acute symptoms include hectic fever, sweats, and emaciation; serious complications include granulomatous erosion of pulmonary bronchi associated with hemoptysis. If untreated, progressive TB may be associated with a high degree of mortality. This infection is frequently observed in immunocompromised individuals with AIDS or a history of illicit IV drug use. --2004', 'Any of the infectious diseases of man and other animals caused by species of MYCOBACTERIUM.']

Endpoint definition

FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 A15, A16, A19, B90.9
Hospital discharge: ICD-9 01[1-2]|018
Hospital discharge: ICD-8 01[1-2]|018
Cause of death: ICD-10 A15, A16, A19, B90.9
Cause of death: ICD-9 01[1-2]|018
Cause of death: ICD-8 01[1-2]|018

2 out of 7 registries used, show all original rules.

2345

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Check minimum number of events None

2345

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Include endpoints None

2345

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Remove individuals based on genotype QC

2244

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TUBERCULOSIS

Control definitions

Controls for this endpoint are individuals that are not cases.

Extra metadata

First used in FinnGen datafreeze DF2

Similar endpoints

List of similar endpoints to Tuberculosis based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

Key figures

All Female Male
Number of individuals 2244 763 1481
Unadjusted prevalence (%) 0.54 0.33 0.81
Mean age at first event (years) 50.97 45.07 54.01

Mortality

Not a core endpoint, no data to show.

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Not a core endpoint, no data to show.

Correlations

Index endpoint: TUBERCULOSIS – Tuberculosis
GWS hits:

Survival analyses between endpoints

Not a core endpoint, no data to show.

Drugs most likely to be purchased after Tuberculosis

Endpoint not on priority list, no data to show.