Tuberculosis

AB1_TUBERCULOSIS

obsolete_tuberculosis: ['A chronic, recurrent infection caused by the bacterium Mycobacterium tuberculosis. Tuberculosis (TB) may affect almost any tissue or organ of the body with the lungs being the most common site of infection. The clinical stages of TB are primary or initial infection, latent or dormant infection, and recrudescent or adult-type TB. Ninety to 95% of primary TB infections may go unrecognized. Histopathologically, tissue lesions consist of granulomas which usually undergo central caseation necrosis. Local symptoms of TB vary according to the part affected; acute symptoms include hectic fever, sweats, and emaciation; serious complications include granulomatous erosion of pulmonary bronchi associated with hemoptysis. If untreated, progressive TB may be associated with a high degree of mortality. This infection is frequently observed in immunocompromised individuals with AIDS or a history of illicit IV drug use. --2004', 'Any of the infectious diseases of man and other animals caused by species of MYCOBACTERIUM.']

Endpoint definition

FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 A15-A19
Hospital discharge: ICD-9 01[0-8]
Hospital discharge: ICD-8 01[0-8]
Cause of death: ICD-10 A15-A19
Cause of death: ICD-9 01[0-8]
Cause of death: ICD-8 01[0-8]

2 out of 7 registries used, show all original rules.

2660

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Check minimum number of events None

2660

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Remove individuals based on genotype QC

2613

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AB1_TUBERCULOSIS

Control definitions

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2

Similar endpoints

Summary Statistics

Key figures

All Female Male
Number of individuals 2613 980 1633
Unadjusted prevalence (%) 0.63 0.43 0.90
Mean age at first event (years) 47.70 41.69 51.31

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.04 [1.51, 2.75] 3.1e-6 1001
15 years 0.01 1.30 [1.06, 1.60] 1.1e-2 403
5 years 0.00 2.31 [1.94, 2.75] 5.8e-21 229
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: AB1_TUBERCULOSIS – Tuberculosis
GWS hits: 1

Survival analyses between endpoints

Plot

before Tuberculosis
after Tuberculosis

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Drugs most likely to be purchased after Tuberculosis

Endpoint not on priority list, no data to show.