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Type1 diabetes, definitions combined

DOID EFO MESH SNOMED Endpoint Browser PheWeb

T1D

diabetic ketoacidosis: The metabolic condition resulted from uncontrolled diabetes mellitus, in which the shift of acid-base status of the body toward the acid side because of loss of base or retention of acids other than carbonic acid is accompanied by the accumulation of ketone bodies in body tissues and fluids.

Endpoint definition

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FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions

not E4_DM2

354634

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Check pre-conditions, main-only, mode, registry filters None

0 out of 7 registries used, show all original rules.

0

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Check minimum number of events None

0

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Include endpoints

4446

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Remove individuals based on genotype QC

4320

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T1D

Control definitions

Control exclude DIABETES_FG
Control conditions not E4_DM2

Extra metadata

First used in FinnGen datafreeze DF2

No data for upset plot.

No data for upset table.

Similar endpoints

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Summary Statistics

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Key figures

All Female Male
Number of individuals 4320 2151 2169
Unadjusted prevalence (%) 1.05 0.93 1.19
Mean age at first event (years) 19.96 18.81 21.11

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.14 7.49 [5.03, 11.17] 4.5e-23 223
15 years 0.04 6.08 [4.18, 8.84] 4.0e-21 91
5 years 0.01 9.83 [6.97, 13.87] 9.9e-39 43
1 year 0.01 26.19 [17.08, 40.16] 1.0e-50 26

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: T1D – Type1 diabetes, definitions combined
GWS hits: 33

Survival analyses between endpoints

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Plot

before Type1 diabetes, definitions combined
after Type1 diabetes, definitions combined

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Drugs most likely to be purchased after Type1 diabetes, definitions combined

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