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Type 1 diabetes, wide definition

DOID EFO MESH SNOMED Endpoint Browser PheWeb

T1D_WIDE

type I diabetes mellitus: A chronic condition characterized by minimal or absent production of insulin by the pancreas.

Endpoint definition

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FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters None

0 out of 7 registries used, show all original rules.

0

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Check minimum number of events None

0

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Include endpoints

9780

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Remove individuals based on genotype QC

9507

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T1D_WIDE

Control definitions

Control exclude DIABETES_FG

Extra metadata

First used in FinnGen datafreeze DF2

No data for upset plot.

No data for upset table.

Similar endpoints

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List of similar endpoints to Type 1 diabetes, wide definition based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

All Female Male
Number of individuals 9507 4577 4930
Unadjusted prevalence (%) 2.31 1.99 2.71
Mean age at first event (years) 28.68 26.46 30.73

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.05 2.57 [1.75, 3.78] 1.3e-6 1339
15 years 0.01 2.03 [1.53, 2.68] 8.2e-7 571
5 years 0.00 2.18 [1.68, 2.82] 4.5e-9 159
1 year 0.00 3.18 [2.20, 4.60] 9.2e-10 41

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: T1D_WIDE – Type 1 diabetes, wide definition
GWS hits: 48

Survival analyses between endpoints

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Plot

before Type 1 diabetes, wide definition
after Type 1 diabetes, wide definition

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Drugs most likely to be purchased after Type 1 diabetes, wide definition

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Endpoint not on priority list, no data to show.