Systemic sclerosis,strict definition

SYSTSCLE_STRICT

scleroderma: Scleroderma is a rare autoimmune connective tissue disorder characterized by abnormal hardening of the skin and, sometimes, other organs. It is classified into two main forms: localized scleroderma and systemic sclerosis (SSc), the latter comprising three subsets; diffuse cutaneous SSc (dcSSc), limited cutaneous SSc (lcSSc) and limited SSc (lSSc) (see these terms).

Endpoint definition

FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions

SYSTSCLE_ICD10

688

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Check pre-conditions, main-only, mode, registry filters

KELA reimbursements: KELA codes ANY
KELA reimbursements: ICD-10 M34

1 out of 7 registries used, show all original rules.

251

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Check minimum number of events None

251

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Include endpoints None

251

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Remove individuals based on genotype QC

244

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SYSTSCLE_STRICT

Control definitions

Control conditions not SYSTSCLE_ICD10

Extra metadata

First used in FinnGen datafreeze DF3

Summary Statistics

Key figures

All Female Male
Number of individuals 244 211 33
Unadjusted prevalence (%) 0.06 0.09 0.02
Mean age at first event (years) 53.78 53.49 55.61

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: SYSTSCLE_STRICT – Systemic sclerosis,strict definition
GWS hits: 1

Survival analyses between endpoints

Plot

before Systemic sclerosis,strict definition
after Systemic sclerosis,strict definition

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Systemic sclerosis,strict definition

Endpoint not on priority list, no data to show.