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This is a non-core endpoint: only basic statistics are computed.

Myelofibrosis

MYELOFIBROSIS

primary myelofibrosis: Myelofibrosis with myeloid metaplasia is a myeloproliferative disease with annual incidence of approximately 1 case per 100,000 individuals and age at diagnosis around 60 (an increased prevalence is noted in Ashkenazi Jews). Clinical manifestations depend on the type of blood cell affected and may include anemia, pallor, splenomegaly, hypermetabolic state, petechiae, ecchymosis, bleeding, lymphadenopathy, hepatomegaly, portal hypertension.

Endpoint definition

FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 C94.5
Hospital discharge: ICD-9 2387A
Hospital discharge: ICD-8 209
Cause of death: ICD-10 C94.5
Cause of death: ICD-9 2387A
Cause of death: ICD-8 209

2 out of 7 registries used, show all original rules.

20

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Check minimum number of events None

20

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Include endpoints None

20

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Remove individuals based on genotype QC

19

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MYELOFIBROSIS

Control definitions

Control exclude MYELOPROF

Extra metadata

First used in FinnGen datafreeze DF2, additional

Summary Statistics

Key figures

All Female Male
Number of individuals 19 7 12
Unadjusted prevalence (%) 0.00 0.00 0.01
Mean age at first event (years) 50.57 39.96 56.76

Mortality

Not a core endpoint, no data to show.

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Not a core endpoint, no data to show.

Correlations

Index endpoint: MYELOFIBROSIS – Myelofibrosis
GWS hits:

Survival analyses between endpoints

Not a core endpoint, no data to show.

Drugs most likely to be purchased after Myelofibrosis

Endpoint not on priority list, no data to show.