Ankylosing hyperostosis [Forestier]

M13_FORESTIER

diffuse idiopathic skeletal hyperostosis: This syndrome is characterized by the association of ankylosing vertebral hyperostosis with hyperkeratosis of the soles and palms.

Endpoint definition

FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 M48.1
Hospital discharge: ICD-9 7216
Cause of death: ICD-10 M48.1
Cause of death: ICD-9 7216

2 out of 7 registries used, show all original rules.

398

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Check minimum number of events None

398

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Include endpoints None

398

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Remove individuals based on genotype QC

384

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M13_FORESTIER

Control definitions

Control exclude M13_DORSOPATHY

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 M48
Name in latin Hyperostosis ancylopoetica

Summary Statistics

Key figures

All Female Male
Number of individuals 384 158 226
Unadjusted prevalence (%) 0.09 0.07 0.12
Mean age at first event (years) 58.44 57.30 59.23

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.06 2.99 [1.75, 5.10] 5.7e-5 52
15 years 0.01 1.48 [0.80, 2.76] 2.2e-1 24
5 years 0.00 1.93 [0.93, 4.02] 7.8e-2 10
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: M13_FORESTIER – Ankylosing hyperostosis [Forestier]
GWS hits: 1

Survival analyses between endpoints

Plot

before Ankylosing hyperostosis [Forestier]
after Ankylosing hyperostosis [Forestier]

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Ankylosing hyperostosis [Forestier]

Endpoint not on priority list, no data to show.