Fibromyalgia

M13_FIBROMYALGIA

fibromyalgia: A chronic disorder of unknown etiology characterized by pain, stiffness, and tenderness in the muscles of neck, shoulders, back, hips, arms, and legs. Other signs and symptoms include headaches, fatigue, sleep disturbances, and painful menstruation.

Endpoint definition

FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 M79.7
Cause of death: ICD-10 M79.7

2 out of 7 registries used, show all original rules.

2784

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Check minimum number of events None

2784

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Include endpoints None

2784

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Remove individuals based on genotype QC

2689

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M13_FIBROMYALGIA

Control definitions

Control exclude M13_SOFTTISSUE

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 M79

Summary Statistics

Key figures

All Female Male
Number of individuals 2689 2505 184
Unadjusted prevalence (%) 0.65 1.09 0.10
Mean age at first event (years) 52.79 52.69 54.08

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.24 13.29 [7.25, 24.33] 5.4e-17 53
15 years 0.03 4.01 [1.96, 8.22] 1.5e-4 16
5 years 0.02 11.34 [6.09, 21.12] 2.0e-14 32
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: M13_FIBROMYALGIA – Fibromyalgia
GWS hits: 1

Survival analyses between endpoints

Plot

before Fibromyalgia
after Fibromyalgia

loading spinner Loading survival analyses plot