Discitis, unspecified

M13_DISCITIS

discitis: Inflammation of an intervertebral disc or disk space which may lead to disk erosion. Until recently, discitis has been defined as a nonbacterial inflammation and has been attributed to aseptic processes (e.g., chemical reaction to an injected substance). However, recent studies provide evidence that infection may be the initial cause, but perhaps not the promoter, of most cases of discitis. Discitis has been diagnosed in patients following discography, myelography, lumbar puncture, paravertebral injection, and obstetrical epidural anesthesia. Discitis following chemonucleolysis (especially with chymopapain) is attributed to chemical reaction by some and to introduction of microorganisms by others.

Endpoint definition

FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 M46.4
Cause of death: ICD-10 M46.4

2 out of 7 registries used, show all original rules.

466

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Check minimum number of events None

466

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Include endpoints None

466

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Remove individuals based on genotype QC

452

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M13_DISCITIS

Control definitions

Control exclude M13_DORSOPATHY

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 M46
Name in latin Discitis non specificata

Summary Statistics

Key figures

All Female Male
Number of individuals 452 166 286
Unadjusted prevalence (%) 0.11 0.07 0.16
Mean age at first event (years) 63.89 61.95 65.02

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.08 4.23 [2.17, 8.24] 2.3e-5 79
15 years 0.01 1.24 [0.59, 2.64] 5.7e-1 22
5 years 0.00 2.36 [1.00, 5.58] 5.0e-2 27
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: M13_DISCITIS – Discitis, unspecified
GWS hits: 1

Survival analyses between endpoints

Plot

before Discitis, unspecified
after Discitis, unspecified

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Discitis, unspecified

Endpoint not on priority list, no data to show.