Ankylosing spondylitis, strict definition

M13_ANKYLOSPON_STRICT

ankylosing spondylitis: An autoimmune chronic inflammatory disorder characterized by inflammation in the vertebral joints of the spine and sacroiliac joints. It predominantly affects young males. Patients present with stiffness and pain in the spine.

Endpoint definition

FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions

M13_ANKYLOSPON_ICD10

3059

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Check pre-conditions, main-only, mode, registry filters

KELA reimbursements: KELA codes ANY
KELA reimbursements: ICD-10 M45

1 out of 7 registries used, show all original rules.

1438

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Check minimum number of events None

1438

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Include endpoints None

1438

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Remove individuals based on genotype QC

1381

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M13_ANKYLOSPON_STRICT

Control definitions

Control conditions not M13_ANKYLOSPON_ICD10

Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF3

Summary Statistics

Key figures

All Female Male
Number of individuals 1381 643 738
Unadjusted prevalence (%) 0.34 0.28 0.41
Mean age at first event (years) 40.49 39.64 41.22

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.01 0.49 [0.09, 2.60] 4.1e-1 25
15 years 0.00 0.50 [0.11, 2.14] 3.5e-1 11
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: M13_ANKYLOSPON_STRICT – Ankylosing spondylitis, strict definition
GWS hits: 8

Survival analyses between endpoints

Plot

before Ankylosing spondylitis, strict definition
after Ankylosing spondylitis, strict definition

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Drugs most likely to be purchased after Ankylosing spondylitis, strict definition

Endpoint not on priority list, no data to show.