Other and unspecified psoriasis

L12_PSORI_NAS

psoriasis: An autoimmune condition characterized by red, well-delineated plaques with silvery scales that are usually on the extensor surfaces and scalp. They can occasionally present with these manifestations: pustules; erythema and scaling in intertriginous areas, and erythroderma, that are often distributed on extensor surfaces and scalp.

Endpoint definition

FinnGen phenotype data

429209 individuals

diagram downward connector

Apply sex-specific rule None

429209

diagram downward connector

Check conditions None

429209

diagram downward connector
diagram bullet

Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 L40.8, L40.9
Hospital discharge: ICD-9 6968X
Hospital discharge: ICD-8 69619
Cause of death: ICD-10 L40.8, L40.9
Cause of death: ICD-9 6968X
Cause of death: ICD-8 69619

2 out of 7 registries used, show all original rules.

1968

diagram downward connector

Check minimum number of events None

1968

diagram downward connector

Include endpoints None

1968

diagram downward connector
diagram bullet diagram downward connector

Remove individuals based on genotype QC

1910

diagram downward connector
L12_PSORI_NAS

Control definitions

Control exclude L12_PAPULOSQUAMOUS

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 1910 938 972
Unadjusted prevalence (%) 0.46 0.41 0.53
Mean age at first event (years) 48.06 46.33 49.73

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.06 2.91 [1.91, 4.43] 7.0e-7 298
15 years 0.01 1.85 [1.37, 2.49] 5.6e-5 137
5 years 0.00 2.93 [2.15, 3.99] 7.9e-12 69
1 year 0.00 5.39 [3.44, 8.47] 2.4e-13 24

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: L12_PSORI_NAS – Other and unspecified psoriasis
GWS hits: 4

Survival analyses between endpoints

Plot

before Other and unspecified psoriasis
after Other and unspecified psoriasis

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Other and unspecified psoriasis

Endpoint not on priority list, no data to show.