Hidradenitis suppurativa

L12_HIDRADENITISSUP

hidradenitis suppurativa: a common (though rarely diagnosed), chronic skin disease characterized by clusters of abscesses or subcutaneous boil-like "infections" (oftentimes free of actual bacteria) that most commonly affects apocrine sweat gland bearing areas, such as the underarms, under the breasts, inner thighs, groin and buttocks.The disease is not contagious. There are indications that it is hereditary among certain ethnic groups and autoimmune in nature. Onset is most common in the late teens and early 20's.

Endpoint definition

FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 L73.2
Hospital discharge: ICD-9 7058C
Cause of death: ICD-10 L73.2
Cause of death: ICD-9 7058C

2 out of 7 registries used, show all original rules.

1114

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Check minimum number of events None

1114

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Include endpoints None

1114

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Remove individuals based on genotype QC

1070

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L12_HIDRADENITISSUP

Control definitions

Control exclude L12_DISORDSKINAPPENDIX

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 L73
Name in latin Hidradenitis suppurativa

Summary Statistics

Key figures

All Female Male
Number of individuals 1070 743 327
Unadjusted prevalence (%) 0.26 0.32 0.18
Mean age at first event (years) 41.74 39.78 46.20

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.07 3.28 [1.05, 10.26] 4.2e-2 50
15 years 0.03 3.40 [1.33, 8.70] 1.1e-2 24
5 years 0.01 5.77 [2.45, 13.58] 5.9e-5 11
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: L12_HIDRADENITISSUP – Hidradenitis suppurativa
GWS hits: 1

Survival analyses between endpoints

Plot

before Hidradenitis suppurativa
after Hidradenitis suppurativa

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Drugs most likely to be purchased after Hidradenitis suppurativa