Dermatitis herpetiformis

L12_DERMATHERP

dermatitis herpetiformis: Dermatitis herpetiformis (DH) is a chronic autoimmune subepidermal bullous disease characterized by grouped pruritic lesions such as papules, urticarial plaques, erythema, and herpetiform vesiculae, with a predominantly symmetrical distribution on extensor surfaces of the elbows (90%), knees (30%), shoulders, buttocks, sacral region, and face of children and adults. Erosions, excoriations and hyperpigmentation usually follow. DH may also appear as a consequence of gluten intolerance.

Endpoint definition

FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 L13.0
Hospital discharge: ICD-9 6940A|6942
Hospital discharge: ICD-8 693
Cause of death: ICD-10 L13.0
Cause of death: ICD-9 6940A|6942
Cause of death: ICD-8 693

2 out of 7 registries used, show all original rules.

541

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Check minimum number of events None

541

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Include endpoints None

541

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Remove individuals based on genotype QC

530

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L12_DERMATHERP

Control definitions

Control exclude L12_BULLOUS

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 L13
Name in latin Dermatitis herpetiformis

Summary Statistics

Key figures

All Female Male
Number of individuals 530 288 242
Unadjusted prevalence (%) 0.13 0.13 0.13
Mean age at first event (years) 45.11 42.87 47.78

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.12 [1.41, 3.18] 2.8e-4 59
15 years 0.01 1.23 [0.75, 2.01] 4.0e-1 26
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: L12_DERMATHERP – Dermatitis herpetiformis
GWS hits: 2

Survival analyses between endpoints

Plot

before Dermatitis herpetiformis
after Dermatitis herpetiformis

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Dermatitis herpetiformis

Endpoint not on priority list, no data to show.