Bullous disorders

L12_BULLOUS

vesiculobullous skin disease: Skin diseases characterized by local or general distributions of vesicles and bullae (i.e. blisters). Both vesicles and bullae are fluid-filled lesions, distinguished by size (vesicles being less than 5–10 mm and bullae being larger than 5–10 mm). Vesiculobullous diseases are classified according to the site and mode of blister formation. Lesions can appear spontaneously or be precipitated by infection, trauma, or sunlight. Etiologies include immunologic and genetic factors. In the case of vesiculobullous diseases which are also immune disorders, the term immunobullous is sometimes used. (From Scientific American Medicine, 1990, and Wikipedia)

Endpoint definition

FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 L10-L14
Cause of death: ICD-10 L10-L14

2 out of 7 registries used, show all original rules.

1548

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Check minimum number of events None

1548

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Remove individuals based on genotype QC

1649

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L12_BULLOUS

Control definitions

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 1649 872 777
Unadjusted prevalence (%) 0.40 0.38 0.43
Mean age at first event (years) 57.84 55.17 60.84

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.07 [1.16, 3.69] 1.4e-2 292
15 years 0.01 1.02 [0.64, 1.64] 9.3e-1 80
5 years 0.01 3.92 [2.74, 5.60] 7.7e-14 106
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: L12_BULLOUS – Bullous disorders
GWS hits: 2

Survival analyses between endpoints

Plot

before Bullous disorders
after Bullous disorders

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Bullous disorders

Endpoint not on priority list, no data to show.