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Atrophic disorders of skin

DOID EFO MESH SNOMED Endpoint Browser PheWeb

L12_ATROPHICSKIN

skin atrophy: The structural changes and the signs and symptoms of chronologically aged skinand those of corticosteroid induced chronicatrophyof theskinare partially very similar.Thinningof epidermis and laxity as well as dryness, purpura and echymoses occur in both conditions.

Endpoint definition

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FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 L90
Cause of death: ICD-10 L90

2 out of 7 registries used, show all original rules.

4206

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Check minimum number of events None

4206

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Include endpoints

4424

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Remove individuals based on genotype QC

4293

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L12_ATROPHICSKIN

Control definitions

Control exclude L12_OTHERSKINSUBCUTIS

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 L80-L99
Name in latin Morbositates atrophicae cutis

Similar endpoints

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Summary Statistics

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Key figures

All Female Male
Number of individuals 4293 3569 724
Unadjusted prevalence (%) 1.04 1.55 0.40
Mean age at first event (years) 54.84 56.07 48.75

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 1.49 [0.78, 2.81] 2.2e-1 195
15 years 0.01 1.11 [0.68, 1.83] 6.8e-1 94
5 years 0.00 1.63 [1.05, 2.54] 3.0e-2 45
1 year 0.00 1.97 [0.98, 3.95] 5.7e-2 10

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: L12_ATROPHICSKIN – Atrophic disorders of skin
GWS hits: 2

Survival analyses between endpoints

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Plot

before Atrophic disorders of skin
after Atrophic disorders of skin

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Drugs most likely to be purchased after Atrophic disorders of skin

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Endpoint not on priority list, no data to show.