Acute appendicitis


appendicitis: Acute inflammation of the vermiform appendix.

Endpoint definition

FinnGen phenotype data

429209 individuals

diagram downward connector

Apply sex-specific rule None


diagram downward connector

Check conditions None


diagram downward connector
diagram bullet

Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 K35
Hospital discharge: ICD-9 540
Hospital discharge: ICD-8 540
Cause of death: ICD-10 K35
Cause of death: ICD-9 540
Cause of death: ICD-8 540

2 out of 7 registries used, show all original rules.


diagram downward connector

Check minimum number of events None


diagram downward connector

Include endpoints None


diagram downward connector
diagram bullet diagram downward connector

Remove individuals based on genotype QC


diagram downward connector

Control definitions

Control exclude K11_APPENDIX

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 K35-K38
Name in latin Appendicitis acuta

Summary Statistics

Key figures

All Female Male
Number of individuals 31628 17142 14486
Unadjusted prevalence (%) 7.68 7.45 7.97
Mean age at first event (years) 34.63 32.64 36.99


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 1.29 [1.11, 1.49] 6.4e-4 2239
15 years 0.01 0.96 [0.84, 1.09] 5.4e-1 878
5 years 0.00 1.30 [1.12, 1.51] 5.4e-4 325
1 year 0.00 2.50 [2.01, 3.11] 1.6e-16 112

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: K11_APPENDACUT – Acute appendicitis
GWS hits: 22

Survival analyses between endpoints


before Acute appendicitis
after Acute appendicitis

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Acute appendicitis