Acute appendicitis, with complications


appendicitis: Acute inflammation of the vermiform appendix.

Endpoint definition

FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None


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Check conditions None


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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 K35.0, K35.1
Hospital discharge: ICD-9 540[0-1]
Hospital discharge: ICD-8 540
Hospital discharge: excluded ICD-8 54090|54099
Cause of death: ICD-10 K35.0, K35.1
Cause of death: ICD-9 540[0-1]
Cause of death: ICD-8 540
Cause of death: excluded ICD-8 54090|54099

2 out of 7 registries used, show all original rules.


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Check minimum number of events None


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Include endpoints None


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Remove individuals based on genotype QC


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Control definitions

Control exclude K11_APPENDIX

Extra metadata

First used in FinnGen datafreeze DF3

Summary Statistics

Key figures

All Female Male
Number of individuals 7358 3511 3847
Unadjusted prevalence (%) 1.79 1.52 2.12
Mean age at first event (years) 36.35 34.05 38.46


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.17 [0.93, 1.49] 1.9e-1 863
15 years 0.01 0.93 [0.77, 1.13] 4.8e-1 359
5 years 0.00 1.26 [1.02, 1.56] 3.0e-2 132
1 year 0.00 2.77 [2.05, 3.75] 3.6e-11 52

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: APPENDACUT_COMPLIC – Acute appendicitis, with complications
GWS hits: 5

Survival analyses between endpoints


before Acute appendicitis, with complications
after Acute appendicitis, with complications

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Acute appendicitis, with complications

Endpoint not on priority list, no data to show.