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Interstitial lung disease endpoints

DOID EFO MESH SNOMED Endpoint Browser PheWeb

ILD_ENDPOINTS

interstitial lung disease: A diverse group of lung diseases that affect the lung parenchyma. They are characterized by an initial inflammation of pulmonary alveoli that extends to the interstitium and beyond leading to diffuse pulmonary fibrosis. Interstitial lung diseases are classified by their etiology (known or unknown causes), and radiological-pathological features.

Endpoint definition

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FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters None

0 out of 7 registries used, show all original rules.

0

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Check minimum number of events None

0

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Include endpoints

4710

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Remove individuals based on genotype QC

4572

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ILD_ENDPOINTS

Control definitions

Controls for this endpoint are individuals that are not cases.

Extra metadata

First used in FinnGen datafreeze DF2

No data for upset plot.

No data for upset table.

Similar endpoints

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List of similar endpoints to Interstitial lung disease endpoints based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

All Female Male
Number of individuals 4572 1779 2793
Unadjusted prevalence (%) 1.11 0.77 1.54
Mean age at first event (years) 65.90 62.87 67.82

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.12 6.29 [4.36, 9.08] 7.7e-23 1403
15 years 0.02 2.46 [1.94, 3.11] 1.0e-13 398
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: ILD_ENDPOINTS – Interstitial lung disease endpoints
GWS hits: 11

Survival analyses between endpoints

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Plot

before Interstitial lung disease endpoints
after Interstitial lung disease endpoints

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Drugs most likely to be purchased after Interstitial lung disease endpoints

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Endpoint not on priority list, no data to show.