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Stroke, excluding SAH

DOID EFO MESH SNOMED Endpoint Browser PheWeb

I9_STR

cerebrovascular disorder: A disorder resulting from inadequate blood flow in the vessels that supply the brain. Representative examples include cerebrovascular ischemia, cerebral embolism, and cerebral infarction.

Endpoint definition

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FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 I61, I63, I64
Hospital discharge: ICD-9 431|4330A|4331A|4339A|4340A|4341A|4349A|436
Hospital discharge: ICD-8 431|433|434|436
Hospital discharge: excluded ICD-10 I63.6
Hospital discharge: excluded ICD-8 43101|43191
Cause of death: ICD-10 I61, I63, I64
Cause of death: ICD-9 431|4330A|4331A|4339A|4340A|4341A|4349A|436
Cause of death: ICD-8 431|433|434|436
Cause of death: excluded ICD-10 I63.6
Cause of death: excluded ICD-8 43101|43191

2 out of 7 registries used, show all original rules.

28482

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Check minimum number of events None

28482

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Include endpoints None

28482

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Remove individuals based on genotype QC

27496

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I9_STR

Control definitions

Control exclude I9_STR_EXH, I9_TIA

Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 27496 10488 17008
Unadjusted prevalence (%) 6.67 4.56 9.36
Mean age at first event (years) 67.06 66.51 67.40

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.10 4.65 [4.11, 5.27] <1e-100 10237
15 years 0.02 2.13 [1.91, 2.39] 1.9e-40 3320
5 years 0.01 4.42 [4.08, 4.80] <1e-100 2840
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: I9_STR – Stroke, excluding SAH
GWS hits: 5

Survival analyses between endpoints

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Plot

before Stroke, excluding SAH
after Stroke, excluding SAH

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Stroke, excluding SAH

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