Myocarditis

I9_MYOCARD

myocarditis: Myocarditis is a condition that is characterized by inflammation of the heart muscle (myocardium). Some affected people have no noticeable symptoms of the condition. When present, signs and symptoms may include chest pain, abnormal heartbeat, shortness of breath, fatigue, signs of infection (i.e. fever, headache, sore throat, diarrhea), and leg swelling. Myocarditis can be caused by a variety of factors including infections (viral, bacterial, parasitic, and fungal), allergic reactions to certain medications, and exposure to certain chemicals. It can also be associated with other inflammatory conditions such as lupus , Wegener's granulomatosis , giant cell arteritis and Takayasu's arteritis. Most cases occur sporadically in people with no family history of the condition. Treatment aims to address the underlying cause of the condition. Medications and, rarely, a heart transplant may be needed if the heart muscle becomes weak. [ https://rarediseases.info.nih.gov/diseases/7137/myocarditis ]

Endpoint definition

FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 I40, I41*
Hospital discharge: ICD-9 422
Hospital discharge: ICD-8 0742|422
Cause of death: ICD-10 I40, I41*
Cause of death: ICD-9 422
Cause of death: ICD-8 0742|422

2 out of 7 registries used, show all original rules.

1712

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Check minimum number of events None

1712

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Include endpoints None

1712

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Remove individuals based on genotype QC

1654

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I9_MYOCARD

Control definitions

Control exclude FG_CVD

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 1654 659 995
Unadjusted prevalence (%) 0.40 0.29 0.55
Mean age at first event (years) 44.15 46.49 42.60

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 1.92 [1.05, 3.49] 3.4e-2 213
15 years 0.01 1.11 [0.66, 1.88] 6.9e-1 64
5 years 0.00 3.23 [2.03, 5.14] 7.8e-7 53
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: I9_MYOCARD – Myocarditis
GWS hits: 1

Survival analyses between endpoints

Plot

before Myocarditis
after Myocarditis

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Myocarditis

Endpoint not on priority list, no data to show.