Disorders of ocular muscles, binocular movement, accommodation and refraction

H7_OCUMUSCLE

trochlear nerve disease: Diseases of the fourth cranial (trochlear) nerve or its nucleus in the midbrain. The nerve crosses as it exits the midbrain dorsally and may be injured along its course through the intracranial space, cavernous sinus, superior orbital fissure, or orbit. Clinical manifestations include weakness of the superior oblique muscle which causes vertical DIPLOPIA that is maximal when the affected eye is adducted and directed inferiorly. Head tilt may be seen as a compensatory mechanism for diplopia and rotation of the visual axis. Common etiologies include CRANIOCEREBRAL TRAUMA and INFRATENTORIAL NEOPLASMS.

Endpoint definition

FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 H49-H52
Cause of death: ICD-10 H49-H52

2 out of 7 registries used, show all original rules.

15420

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Check minimum number of events None

15420

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Remove individuals based on genotype QC

18153

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H7_OCUMUSCLE

Control definitions

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 18153 11548 6605
Unadjusted prevalence (%) 4.41 5.02 3.63
Mean age at first event (years) 38.78 36.61 42.57

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 1.82 [1.40, 2.35] 5.7e-6 1134
15 years 0.01 1.15 [0.86, 1.54] 3.3e-1 499
5 years 0.00 2.03 [1.55, 2.66] 2.7e-7 269
1 year 0.00 5.14 [3.87, 6.83] 1.3e-29 127

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: H7_OCUMUSCLE – Disorders of ocular muscles, binocular movement, accommodation and refraction
GWS hits: 1

Survival analyses between endpoints

Plot

before Disorders of ocular muscles, binocular movement, accommodation and refraction
after Disorders of ocular muscles, binocular movement, accommodation and refraction

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Disorders of ocular muscles, binocular movement, accommodation and refraction

Endpoint not on priority list, no data to show.