Hereditary corneal dystrophies

DOID MESH Endpoint Browser PheWeb

H7_KERATOCONUS

No definition available.

Endpoint definition

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FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 H18.5

Hospital discharge: ICD-9 3715

Hospital discharge: ICD-8 37102

Cause of death: ICD-10 H18.5

Cause of death: ICD-9 3715

Cause of death: ICD-8 37102

2 out of 7 registries used, show all original rules.

832

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Check minimum number of events None

832

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Include endpoints None

832

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Remove individuals based on genotype QC

812

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H7_KERATOCONUS

Control definitions

Control exclude H7_SCLERACORNEA

Extra metadata

Level in the ICD hierarchy 4

First used in FinnGen datafreeze DF2

Parent code in ICD-10 H18

Name in latin Dystrophia corneae hereditaria

NAME	H7_KERATOCONUS
CONTROL_EXCLUDE	H7_SCLERACORNEA
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	H185
HD_ICD_9	3715
HD_ICD_8	37102
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	H185
COD_ICD_9	3715
COD_ICD_8	37102
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

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Similar endpoints

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List of similar endpoints to Hereditary corneal dystrophies based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	812	547	265
Unadjusted prevalence (%)	0.20	0.24	0.15
Mean age at first event (years)	62.52	61.96	63.68

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.05	2.68 [1.26, 5.74]	1.1e-2	63
15 years	0.01	1.66 [0.73, 3.79]	2.3e-1	31
5 years	0.00	2.61 [1.04, 6.57]	4.1e-2	26
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: H7_KERATOCONUS – Hereditary corneal dystrophies
GWS hits: 9

Survival analyses between endpoints

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Plot

before Hereditary corneal dystrophies
after Hereditary corneal dystrophies

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Table

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Drugs most likely to be purchased after Hereditary corneal dystrophies

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Endpoint not on priority list, no data to show.