Other disorders of cornea

DOID EFO MESH SNOMED Endpoint Browser PheWeb

H7_CORNEALOTH

corneal disease: A non-neoplastic or neoplastic disorder that affects the cornea. Representative examples include keratitis, bullous keratopathy, and squamous cell carcinoma.

Endpoint definition

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FinnGen phenotype data

429209 individuals

Apply sex-specific rule None

429209

Check conditions None

429209

Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 H18

Cause of death: ICD-10 H18

2 out of 7 registries used, show all original rules.

2785

Check minimum number of events None

2785

Include endpoints

H7_CORNEAPIGMENT

H7_BULLKERATOPATHY

H7_CORNEALOEDEMA

H7_CORNEALMEMBRANE

H7_CORNEALDYSTROPHY

H7_KERATOCONUS

H7_CORNEALDEFORM

H7_CORNEALNAS

2881

Remove individuals based on genotype QC

2776

H7_CORNEALOTH

Control definitions

Control exclude H7_SCLERACORNEA

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Parent code in ICD-10 H15-H22

Name in latin Aliae morbositates corneae

NAME	H7_CORNEALOTH
CONTROL_EXCLUDE	H7_SCLERACORNEA
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE	H7_CORNEAPIGMENT\|H7_BULLKERATOPATHY\|H7_CORNEALOEDEMA\|H7_CORNEALMEMBRANE\|H7_CORNEALDYSTROPHY\|H7_KERATOCONUS\|H7_CORNEALDEFORM\|H7_CORNEALNAS
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	H18
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	H18
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

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Similar endpoints

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List of similar endpoints to Other disorders of cornea based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

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Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	2776	1588	1188
Unadjusted prevalence (%)	0.67	0.69	0.65
Mean age at first event (years)	54.14	55.03	52.96

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.05	2.51 [1.54, 4.08]	2.2e-4	235
15 years	0.01	1.57 [1.09, 2.26]	1.5e-2	102
5 years	0.00	3.09 [2.19, 4.36]	1.5e-10	85
1 year	0.00	2.54 [1.42, 4.55]	1.7e-3	14

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: H7_CORNEALOTH – Other disorders of cornea
GWS hits: 7

Survival analyses between endpoints

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Plot

before Other disorders of cornea
after Other disorders of cornea

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Table

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Drugs most likely to be purchased after Other disorders of cornea

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Endpoint not on priority list, no data to show.

≡ Risteys

R10

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R3