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Generalized epilepsy, strict definition

DOID EFO MESH SNOMED Endpoint Browser PheWeb

GE_STRICT

generalised epilepsy: A chronic condition characterised by recurrent generalised seizures.

Endpoint definition

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FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions

not FE

421412

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Check pre-conditions, main-only, mode, registry filters None

0 out of 7 registries used, show all original rules.

0

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Check minimum number of events None

0

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Include endpoints

GE

767

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Remove individuals based on genotype QC

725

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GE_STRICT

Control definitions

Control exclude G6_EPLEPSY
Control conditions not FE

Extra metadata

First used in FinnGen datafreeze DF3

No data for upset plot.

No data for upset table.

Summary Statistics

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Key figures

All Female Male
Number of individuals 725 451 274
Unadjusted prevalence (%) 0.18 0.20 0.15
Mean age at first event (years) 29.70 28.11 32.34

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.08 4.08 [1.59, 10.48] 3.5e-3 68
15 years 0.03 3.35 [1.69, 6.65] 5.3e-4 31
5 years 0.01 5.48 [2.99, 10.07] 4.0e-8 17
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: GE_STRICT – Generalized epilepsy, strict definition
GWS hits:

Survival analyses between endpoints

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Plot

before Generalized epilepsy, strict definition
after Generalized epilepsy, strict definition

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Drugs most likely to be purchased after Generalized epilepsy, strict definition

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Endpoint not on priority list, no data to show.