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Generalized epilepsy

DOID EFO MESH SNOMED Endpoint Browser PheWeb

GE

generalised epilepsy: A chronic condition characterised by recurrent generalised seizures.

Endpoint definition

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FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 G40.3
Hospital discharge: ICD-9 345[0-3]
Hospital discharge: ICD-8 34519
Hospital discharge: excluded ICD-8 34511
Cause of death: ICD-10 G40.3
Cause of death: ICD-9 345[0-3]
Cause of death: ICD-8 34519
Cause of death: excluded ICD-8 34511

2 out of 7 registries used, show all original rules.

1481

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Check minimum number of events None

1481

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Include endpoints None

1481

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Remove individuals based on genotype QC

1413

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GE

Control definitions

Control exclude G6_EPLEPSY

Extra metadata

First used in FinnGen datafreeze DF3

Summary Statistics

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Key figures

All Female Male
Number of individuals 1413 862 551
Unadjusted prevalence (%) 0.34 0.37 0.30
Mean age at first event (years) 30.55 28.37 33.96

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 1.80 [0.75, 4.35] 1.9e-1 157
15 years 0.01 1.55 [0.78, 3.10] 2.1e-1 67
5 years 0.00 2.52 [1.38, 4.59] 2.5e-3 29
1 year 0.00 5.42 [2.67, 10.97] 2.7e-6 12

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: GE – Generalized epilepsy
GWS hits: 1

Survival analyses between endpoints

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Plot

before Generalized epilepsy
after Generalized epilepsy

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Generalized epilepsy

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Endpoint not on priority list, no data to show.