Parkinson's disease


Parkinson's disease: A progressive degenerative disorder of the central nervous system characterized by loss of dopamine producing neurons in the substantia nigra and the presence of Lewy bodies in the substantia nigra and locus coeruleus. Signs and symptoms include tremor which is most pronounced during rest, muscle rigidity, slowing of the voluntary movements, a tendency to fall back, and a mask-like facial expression.

Endpoint definition

FinnGen phenotype data

429209 individuals

diagram downward connector

Apply sex-specific rule None


diagram downward connector

Check conditions None


diagram downward connector
diagram bullet

Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 G20
Hospital discharge: ICD-9 3320A
Hospital discharge: ICD-8 34200
Cause of death: ICD-10 G20
Cause of death: ICD-9 3320A
Cause of death: ICD-8 34200
KELA reimbursements: KELA codes 110

3 out of 7 registries used, show all original rules.


diagram downward connector

Check minimum number of events None


diagram downward connector

Include endpoints None


diagram downward connector
diagram bullet diagram downward connector

Remove individuals based on genotype QC


diagram downward connector

Control definitions

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 G20-G26
Name in latin Morbus Parkinson

Similar endpoints

List of similar endpoints to Parkinson's disease based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

Key figures

All Female Male
Number of individuals 4681 1858 2823
Unadjusted prevalence (%) 1.14 0.81 1.55
Mean age at first event (years) 65.81 64.14 66.91


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.09 4.35 [3.40, 5.57] 2.1e-31 1426
15 years 0.02 2.49 [2.03, 3.06] 2.0e-18 681
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: G6_PARKINSON – Parkinson's disease
GWS hits: 5

Survival analyses between endpoints


before Parkinson's disease
after Parkinson's disease

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Parkinson's disease