MS-disease / Multiple Sclerosis


multiple sclerosis: A progressive autoimmune disorder affecting the central nervous system resulting in demyelination. Patients develop physical and cognitive impairments that correspond with the affected nerve fibers.

Endpoint definition

FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None


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Check conditions None


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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 G35
Hospital discharge: ICD-9 340
Hospital discharge: ICD-8 34099
Cause of death: ICD-10 G35
Cause of death: ICD-9 340
Cause of death: ICD-8 34099
KELA reimbursements: KELA codes 109

3 out of 7 registries used, show all original rules.


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Check minimum number of events None


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Include endpoints None


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Remove individuals based on genotype QC


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Control definitions

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 G35-G37
Name in latin Sclerosis multiplex

Summary Statistics

Key figures

All Female Male
Number of individuals 2409 1819 590
Unadjusted prevalence (%) 0.58 0.79 0.32
Mean age at first event (years) 39.41 38.35 42.68


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.06 3.12 [2.12, 4.59] 8.7e-9 117
15 years 0.02 2.13 [1.46, 3.11] 8.1e-5 49
5 years 0.00 3.55 [2.30, 5.48] 1.1e-8 25
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: G6_MS – MS-disease / Multiple Sclerosis
GWS hits: 9

Survival analyses between endpoints


before MS-disease / Multiple Sclerosis
after MS-disease / Multiple Sclerosis

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after MS-disease / Multiple Sclerosis