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MS-disease / Multiple Sclerosis

DOID EFO MESH SNOMED Endpoint Browser PheWeb

G6_MS

multiple sclerosis: A progressive autoimmune disorder affecting the central nervous system resulting in demyelination. Patients develop physical and cognitive impairments that correspond with the affected nerve fibers.

Endpoint definition

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FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 G35
Hospital discharge: ICD-9 340
Hospital discharge: ICD-8 34099
Cause of death: ICD-10 G35
Cause of death: ICD-9 340
Cause of death: ICD-8 34099
KELA reimbursements: KELA codes 109

3 out of 7 registries used, show all original rules.

2533

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Check minimum number of events None

2533

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Include endpoints None

2533

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Remove individuals based on genotype QC

2409

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G6_MS

Control definitions

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 G35-G37
Name in latin Sclerosis multiplex

Summary Statistics

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Key figures

All Female Male
Number of individuals 2409 1819 590
Unadjusted prevalence (%) 0.58 0.79 0.32
Mean age at first event (years) 39.41 38.35 42.68

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.06 3.12 [2.12, 4.59] 8.7e-9 117
15 years 0.02 2.13 [1.46, 3.11] 8.1e-5 49
5 years 0.00 3.55 [2.30, 5.48] 1.1e-8 25
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: G6_MS – MS-disease / Multiple Sclerosis
GWS hits: 9

Survival analyses between endpoints

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Plot

before MS-disease / Multiple Sclerosis
after MS-disease / Multiple Sclerosis

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after MS-disease / Multiple Sclerosis

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