Migraine

G6_MIGRAINE

migraine disorder: A common, severe type of vascular headache often associated with increased sympathetic activity, resulting in nausea, vomiting, and light sensitivity.

Endpoint definition

FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 G43
Hospital discharge: ICD-9 346
Hospital discharge: ICD-8 346
Hospital discharge: excluded ICD-8 34601
Cause of death: ICD-10 G43
Cause of death: ICD-9 346
Cause of death: ICD-8 346
Cause of death: excluded ICD-8 34601

2 out of 7 registries used, show all original rules.

21699

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Check minimum number of events None

21699

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Include endpoints

21699

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Remove individuals based on genotype QC

20908

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G6_MIGRAINE

Control definitions

Control exclude G6_EPIPAROX

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 G40-G47
Name in latin Hemicrania

Summary Statistics

Key figures

All Female Male
Number of individuals 20908 17285 3623
Unadjusted prevalence (%) 5.07 7.51 1.99
Mean age at first event (years) 40.47 40.14 42.00

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 1.53 [1.11, 2.12] 9.0e-3 508
15 years 0.01 1.27 [0.96, 1.70] 9.5e-2 245
5 years 0.00 1.62 [1.19, 2.19] 1.9e-3 87
1 year 0.00 3.00 [1.97, 4.57] 2.9e-7 30

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: G6_MIGRAINE – Migraine
GWS hits: 4

Survival analyses between endpoints

Plot

before Migraine
after Migraine

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