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Mental and behavioural disorders due to opioids

DOID EFO MESH SNOMED Endpoint Browser PheWeb

F5_OPIOIDS

opioid dependence: Disorders related or resulting from abuse or mis-use of opioids.

Endpoint definition

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FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 F11
Hospital discharge: ICD-9 3040|3055
Hospital discharge: ICD-8 304[0-1]
Cause of death: ICD-10 F11
Cause of death: ICD-9 3040|3055
Cause of death: ICD-8 304[0-1]

2 out of 7 registries used, show all original rules.

1272

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Check minimum number of events None

1272

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Include endpoints None

1272

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Remove individuals based on genotype QC

1197

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F5_OPIOIDS

Control definitions

Control exclude F5_SUBSNOALCO

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 F10-F19
Name in latin Perturbationes mentis et modi se gerendi ex usu opioidum

Summary Statistics

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Key figures

All Female Male
Number of individuals 1197 532 665
Unadjusted prevalence (%) 0.29 0.23 0.37
Mean age at first event (years) 35.83 35.81 35.85

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.21 11.55 [7.06, 18.91] 2.2e-22 96
15 years 0.04 5.70 [3.30, 9.83] 4.0e-10 41
5 years 0.01 8.97 [5.09, 15.78] 2.9e-14 25
1 year 0.01 25.56 [12.79, 51.06] 4.4e-20 16

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: F5_OPIOIDS – Mental and behavioural disorders due to opioids
GWS hits:

Survival analyses between endpoints

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Plot

before Mental and behavioural disorders due to opioids
after Mental and behavioural disorders due to opioids

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Drugs most likely to be purchased after Mental and behavioural disorders due to opioids

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Endpoint not on priority list, no data to show.