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Mild mental retardation

DOID EFO MESH Endpoint Browser PheWeb

F5_MILDRET

mental retardation: ['Subnormal intellectual functioning which originates during the developmental period. This has multiple potential etiologies, including genetic defects and perinatal insults. Intelligence quotient (IQ) scores are commonly used to determine whether an individual is mentally retarded. IQ scores between 70 and 79 are in the borderline mentally retarded range. Scores below 67 are in the retarded range. (Joynt, Clinical Neurology, 1992, Ch55, p28)']

Endpoint definition

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FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 F70
Hospital discharge: ICD-9 3170
Hospital discharge: ICD-8 311
Cause of death: ICD-10 F70
Cause of death: ICD-9 3170
Cause of death: ICD-8 311

2 out of 7 registries used, show all original rules.

850

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Check minimum number of events None

850

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Include endpoints None

850

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Remove individuals based on genotype QC

800

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F5_MILDRET

Control definitions

Control exclude F5_MENTRET

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 F70-F79
Name in latin Retardatio mentalis levis

Summary Statistics

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Key figures

All Female Male
Number of individuals 800 399 401
Unadjusted prevalence (%) 0.19 0.17 0.22
Mean age at first event (years) 28.80 29.21 28.39

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.08 3.73 [1.87, 7.45] 1.9e-4 84
15 years 0.01 1.97 [0.84, 4.61] 1.2e-1 31
5 years 0.00 3.09 [1.12, 8.51] 2.9e-2 15
1 year 0.00 12.07 [4.20, 34.71] 3.8e-6 10

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: F5_MILDRET – Mild mental retardation
GWS hits: 2

Survival analyses between endpoints

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Plot

before Mild mental retardation
after Mild mental retardation

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Mild mental retardation

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Endpoint not on priority list, no data to show.