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Manic episode

DOID EFO MESH SNOMED Endpoint Browser PheWeb

F5_MANIA

bipolar disorder: A disorder of the brain that causes unusual shifts in mood, energy, activity levels and the ability to carry out day-to-day tasks. Often these moods range and shift from periods of elation and energized behavior to those of hopelessness and depression.

Endpoint definition

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FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 F30
Cause of death: ICD-10 F30

2 out of 7 registries used, show all original rules.

1047

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Check minimum number of events None

1047

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Include endpoints None

1047

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Remove individuals based on genotype QC

992

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F5_MANIA

Control definitions

Control exclude F5_MOOD

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 F30-F39
Name in latin Mania

Summary Statistics

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Key figures

All Female Male
Number of individuals 992 545 447
Unadjusted prevalence (%) 0.24 0.24 0.25
Mean age at first event (years) 44.66 42.93 46.77

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.12 5.95 [3.75, 9.44] 3.8e-14 105
15 years 0.02 3.20 [2.03, 5.04] 5.4e-7 45
5 years 0.01 5.00 [3.05, 8.18] 1.6e-10 30
1 year 0.00 10.40 [5.01, 21.56] 3.1e-10 13

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: F5_MANIA – Manic episode
GWS hits:

Survival analyses between endpoints

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Plot

before Manic episode
after Manic episode

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Manic episode

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Endpoint not on priority list, no data to show.