Any mental disorder


vascular dementia: A degenerative vascular disorder affecting the brain. It is caused by the blockage of the blood supply to the brain. It is manifested with decline of memory and cognitive functions.

Endpoint definition

FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None


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Check conditions None


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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 F0[0-3]|F051|G30|F[1-9]
Hospital discharge: ICD-9 29[0-2]|2941A|29[5-9]|30|31[2-9]|3310A|3311A|4378A
Hospital discharge: ICD-8 29[0-1]|29440|29[5-9]|30[0-1]|3021|30[3-8]|310
Cause of death: ICD-10 F0[0-3]|F051|G30|F[1-9]
Cause of death: ICD-9 29[0-2]|2941A|29[5-9]|30|31[2-9]|3310A|3311A|4378A
Cause of death: ICD-8 29[0-1]|29440|29[5-9]|30[0-1]|3021|30[3-8]|310

2 out of 7 registries used, show all original rules.


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Check minimum number of events None


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Remove individuals based on genotype QC


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Control definitions

Controls for this endpoint are individuals that are not cases.

Extra metadata

First used in FinnGen datafreeze DF9

Summary Statistics

Key figures

All Female Male
Number of individuals 110300 63110 47190
Unadjusted prevalence (%) 26.77 27.41 25.97
Mean age at first event (years) 43.96 41.33 47.47


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.08 4.79 [4.39, 5.24] <1e-100 18105
15 years 0.02 2.77 [2.56, 2.98] <1e-100 5729
5 years 0.01 5.93 [5.58, 6.31] <1e-100 5518
1 year 0.00 17.77 [16.25, 19.42] <1e-100 4081

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: KRA_PSY_ANYMENTAL – Any mental disorder
GWS hits: 27

Survival analyses between endpoints


before Any mental disorder
after Any mental disorder

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Drugs most likely to be purchased after Any mental disorder