≡ Risteys
R10

Documentation Changelog GitHub Contact & Feedback

Depression

DOID EFO MESH Endpoint Browser PheWeb

F5_DEPRESSIO

unipolar depression: A mood disorder having a clinical course involving one or more episodes of serious psychological depression that last two or more weeks each, do not have intervening episodes of mania or hypomania, and are characterized by a loss of interest or pleasure in almost all activities and by some or all of disturbances of appetite, sleep, or psychomotor functioning, a decrease in energy, difficulties in thinking or making decisions, loss of self-esteem or feelings of guilt, and suicidal thoughts or attempts.

Endpoint definition

↥
FinnGen phenotype data

429209 individuals

diagram downward connector

Apply sex-specific rule None

429209

diagram downward connector

Check conditions None

429209

diagram downward connector
diagram bullet

Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 F32, F33
Hospital discharge: ICD-9 2961|2968|3004
Cause of death: ICD-10 F32, F33
Cause of death: ICD-9 2961|2968|3004

2 out of 7 registries used, show all original rules.

49658

diagram downward connector

Check minimum number of events None

49658

diagram downward connector
diagram bullet diagram downward connector

Include endpoints

49693

diagram downward connector
diagram bullet diagram downward connector

Remove individuals based on genotype QC

47695

diagram downward connector
F5_DEPRESSIO

Control definitions

Control exclude F5_MOOD

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF9

Summary Statistics

↥

Key figures

All Female Male
Number of individuals 47695 32178 15517
Unadjusted prevalence (%) 11.58 13.98 8.54
Mean age at first event (years) 41.76 40.17 45.04

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.06 2.90 [2.48, 3.40] 1.1e-39 3593
15 years 0.01 2.15 [1.91, 2.41] 6.6e-39 1529
5 years 0.00 3.66 [3.30, 4.05] <1e-100 834
1 year 0.00 8.99 [7.85, 10.30] <1e-100 414

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

↥

Index endpoint: F5_DEPRESSIO – Depression
GWS hits: 23

Survival analyses between endpoints

↥

Plot

before Depression
after Depression

loading spinner Loading survival analyses plot