≡ Risteys
R10

Documentation Changelog GitHub Contact & Feedback

Bipolar affective disorders

DOID EFO MESH SNOMED Endpoint Browser PheWeb

F5_BIPO

bipolar disorder: A disorder of the brain that causes unusual shifts in mood, energy, activity levels and the ability to carry out day-to-day tasks. Often these moods range and shift from periods of elation and energized behavior to those of hopelessness and depression.

Endpoint definition

↥
FinnGen phenotype data

429209 individuals

diagram downward connector

Apply sex-specific rule None

429209

diagram downward connector

Check conditions None

429209

diagram downward connector
diagram bullet

Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 F31
Hospital discharge: ICD-9 296[2-7]
Hospital discharge: ICD-8 296
Hospital discharge: excluded ICD-8 2960|29699
Cause of death: ICD-10 F31
Cause of death: ICD-9 296[2-7]
Cause of death: ICD-8 296
Cause of death: excluded ICD-8 2960|29699

2 out of 7 registries used, show all original rules.

7865

diagram downward connector

Check minimum number of events None

7865

diagram downward connector

Include endpoints None

7865

diagram downward connector
diagram bullet diagram downward connector

Remove individuals based on genotype QC

7569

diagram downward connector
F5_BIPO

Control definitions

Control exclude F5_MOOD

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 F30-F39
Name in latin Perturbatio affectiva bipolaris

Summary Statistics

↥

Key figures

All Female Male
Number of individuals 7569 4823 2746
Unadjusted prevalence (%) 1.84 2.09 1.51
Mean age at first event (years) 39.55 37.83 42.57

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.06 3.01 [2.10, 4.32] 2.0e-9 484
15 years 0.02 2.43 [1.83, 3.22] 6.6e-10 234
5 years 0.00 2.72 [2.00, 3.69] 1.3e-10 76
1 year 0.00 6.32 [4.20, 9.52] 1.1e-18 31

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

↥

Index endpoint: F5_BIPO – Bipolar affective disorders
GWS hits: 2

Survival analyses between endpoints

↥

Plot

before Bipolar affective disorders
after Bipolar affective disorders

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Bipolar affective disorders

↥