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Mixed hyperlipidaemia

DOID EFO MESH Endpoint Browser PheWeb

E4_HYPERLIPMIX

obsolete_familial combined hyperlipidemia: ['A type of familial lipid metabolism disorder characterized by a variable pattern of elevated plasma CHOLESTEROL and/or TRIGLYCERIDES. Multiple genes on different chromosomes may be involved, such as the major late transcription factor (UPSTREAM STIMULATORY FACTORS) on CHROMOSOME 1.']

Endpoint definition

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FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 E78.2
Hospital discharge: ICD-9 2722
Cause of death: ICD-10 E78.2
Cause of death: ICD-9 2722

2 out of 7 registries used, show all original rules.

1224

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Check minimum number of events None

1224

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Include endpoints None

1224

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Remove individuals based on genotype QC

1184

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E4_HYPERLIPMIX

Control definitions

Control exclude E4_METABOLIA

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 E78

Summary Statistics

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Key figures

All Female Male
Number of individuals 1184 410 774
Unadjusted prevalence (%) 0.29 0.18 0.43
Mean age at first event (years) 55.75 56.65 55.27

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.06 3.24 [2.03, 5.15] 7.6e-7 250
15 years 0.02 2.37 [1.68, 3.34] 8.0e-7 117
5 years 0.00 3.13 [2.16, 4.55] 2.0e-9 47
1 year 0.00 7.62 [4.66, 12.46] 5.4e-16 21

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_HYPERLIPMIX – Mixed hyperlipidaemia
GWS hits: 6

Survival analyses between endpoints

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Plot

before Mixed hyperlipidaemia
after Mixed hyperlipidaemia

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Mixed hyperlipidaemia

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Endpoint not on priority list, no data to show.