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Type 1 diabetes with renal complications

MESH Endpoint Browser PheWeb

E4_DM1REN

No definition available.

Endpoint definition

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FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 E10.2+, E10.2+N08.39
Hospital discharge: ICD-9 2503B
Cause of death: ICD-10 E10.2+, E10.2+N08.39
Cause of death: ICD-9 2503B

2 out of 7 registries used, show all original rules.

1720

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Check minimum number of events None

1720

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Include endpoints None

1720

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Remove individuals based on genotype QC

1670

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E4_DM1REN

Control definitions

Control exclude E4_DIABETES

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF3

Summary Statistics

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Key figures

All Female Male
Number of individuals 1670 731 939
Unadjusted prevalence (%) 0.41 0.32 0.52
Mean age at first event (years) 42.81 38.98 45.79

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.14 7.14 [3.78, 13.46] 1.3e-9 369
15 years 0.04 5.78 [3.58, 9.35] 8.1e-13 154
5 years 0.02 13.01 [9.39, 18.03] 1.3e-53 115
1 year 0.00 17.81 [11.70, 27.11] 3.9e-41 33

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_DM1REN – Type 1 diabetes with renal complications
GWS hits: 6

Survival analyses between endpoints

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Plot

before Type 1 diabetes with renal complications
after Type 1 diabetes with renal complications

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Type 1 diabetes with renal complications

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Endpoint not on priority list, no data to show.