Drug-induced neutropenia

Endpoint Browser PheWeb

DRUGADVERS_NEUTROPENIA

No definition available.

Endpoint definition

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FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 D70.82#

1 out of 7 registries used, show all original rules.

2192

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Check minimum number of events None

2192

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Include endpoints None

2192

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Remove individuals based on genotype QC

2124

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DRUGADVERS_NEUTROPENIA

Control definitions

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy C

First used in FinnGen datafreeze DF5

NAME	DRUGADVERS_NEUTROPENIA
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	D7082
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

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Or the full data table

Similar endpoints

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List of similar endpoints to Drug-induced neutropenia based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	2124	1359	765
Unadjusted prevalence (%)	0.52	0.59	0.42
Mean age at first event (years)	59.34	57.71	62.24

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.58	43.26 [28.45, 65.77]	1.6e-69	540
15 years	0.04	5.59 [3.60, 8.69]	2.1e-14	62
5 years	0.04	26.97 [18.97, 38.33]	2.4e-75	186
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: DRUGADVERS_NEUTROPENIA – Drug-induced neutropenia
GWS hits:

Survival analyses between endpoints

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Plot

before Drug-induced neutropenia
after Drug-induced neutropenia

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Table

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Drugs most likely to be purchased after Drug-induced neutropenia

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Endpoint not on priority list, no data to show.