≡ Risteys
R10

Documentation Changelog GitHub Contact & Feedback

Sarcoidosis

DOID EFO MESH Endpoint Browser PheWeb

D3_SARCOIDOSIS

obsolete_sarcoidosis: ['An idiopathic inflammatory disorder characterized by the formation of non-necrotizing epithelioid granulomas which contain giant cells. It usually affects the lungs, lymph nodes, liver, and skin.', 'An idiopathic systemic inflammatory granulomatous disorder comprised of epithelioid and multinucleated giant cells with little necrosis. It usually invades the lungs with fibrosis and may also involve lymph nodes, skin, liver, spleen, eyes, phalangeal bones, and parotid glands.']

Endpoint definition

↥
FinnGen phenotype data

429209 individuals

diagram downward connector

Apply sex-specific rule None

429209

diagram downward connector

Check conditions None

429209

diagram downward connector
diagram bullet

Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 D86
Hospital discharge: ICD-9 135
Hospital discharge: ICD-8 135
Cause of death: ICD-10 D86
Cause of death: ICD-9 135
Cause of death: ICD-8 135
KELA reimbursements: KELA codes 132

3 out of 7 registries used, show all original rules.

4536

diagram downward connector

Check minimum number of events None

4536

diagram downward connector

Include endpoints None

4536

diagram downward connector
diagram bullet diagram downward connector

Remove individuals based on genotype QC

4399

diagram downward connector
D3_SARCOIDOSIS

Control definitions

Control exclude D3_IMMUNEMECHANISM

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 D80-D89
Name in latin Sarcoidosis

Summary Statistics

↥

Key figures

All Female Male
Number of individuals 4399 2465 1934
Unadjusted prevalence (%) 1.07 1.07 1.06
Mean age at first event (years) 47.05 47.76 46.14

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.17 [0.82, 1.66] 3.8e-1 387
15 years 0.01 0.97 [0.71, 1.31] 8.2e-1 149
5 years 0.00 1.57 [1.13, 2.18] 6.6e-3 60
1 year 0.00 5.00 [3.37, 7.41] 1.3e-15 34

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

↥

Index endpoint: D3_SARCOIDOSIS – Sarcoidosis
GWS hits: 14

Survival analyses between endpoints

↥

Plot

before Sarcoidosis
after Sarcoidosis

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Sarcoidosis

↥

Endpoint not on priority list, no data to show.