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Crohn's disease NAS

DOID EFO MESH SNOMED Endpoint Browser PheWeb

CHRONNAS

Crohn's disease: A gastrointestinal disorder characterized by chronic inflammation involving all layers of the intestinal wall, noncaseating granulomas affecting the intestinal wall and regional lymph nodes, and transmural fibrosis. Crohn disease most commonly involves the terminal ileum; the colon is the second most common site of involvement.

Endpoint definition

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FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 K50.9
Cause of death: ICD-10 K50.9

2 out of 7 registries used, show all original rules.

2264

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Check minimum number of events None

2264

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Include endpoints None

2264

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Remove individuals based on genotype QC

2191

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CHRONNAS

Control definitions

Control exclude K11_ENERCOLNONINF

Extra metadata

First used in FinnGen datafreeze DF2
Parent code in ICD-10 K50
Name in latin Morbus Crohn non specificatus

Summary Statistics

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Key figures

All Female Male
Number of individuals 2191 1212 979
Unadjusted prevalence (%) 0.53 0.53 0.54
Mean age at first event (years) 44.19 42.53 46.25

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.12 6.13 [4.46, 8.43] 4.8e-29 172
15 years 0.02 2.63 [1.83, 3.76] 1.5e-7 63
5 years 0.01 5.90 [4.27, 8.17] 8.4e-27 60
1 year 0.00 14.02 [9.11, 21.58] 3.5e-33 33

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: CHRONNAS – Crohn's disease NAS
GWS hits: 9

Survival analyses between endpoints

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Plot

before Crohn's disease NAS
after Crohn's disease NAS

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Crohn's disease NAS

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Endpoint not on priority list, no data to show.