Congenital malformations of the nervous system

DOID MESH Endpoint Browser PheWeb

Q17_CONGEN_MALFO_NERVOUS_SYSTEM

No definition available.

Endpoint definition

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FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 Q00-Q07

Cause of death: ICD-10 Q00-Q07

2 out of 7 registries used, show all original rules.

614

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Check minimum number of events None

614

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Include endpoints

Q17_ANENC_SIMIL_MALFO

Q17_ENCEPHALOCELE

Q17_MICROCEPHALY

Q17_CONGEN_HYDROCEPHALUS

Q17_OTHER_CONGEN_MALFO_BRAIN

Q17_SPINA_BIFIDA

Q17_OTHER_CONGEN_MALFO_SPINAL_CORD

Q17_OTHER_CONGEN_MALFO_NERVOUS_SYSTEM

667

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Remove individuals based on genotype QC

637

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Q17_CONGEN_MALFO_NERVOUS_SYSTEM

Control definitions

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 2

First used in FinnGen datafreeze DF4

Parent code in ICD-10 Q

Name in latin Malformationes congenitae systematis nervosi

NAME	Q17_CONGEN_MALFO_NERVOUS_SYSTEM
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE	Q17_ANENC_SIMIL_MALFO\|Q17_ENCEPHALOCELE\|Q17_MICROCEPHALY\|Q17_CONGEN_HYDROCEPHALUS\|Q17_OTHER_CONGEN_MALFO_BRAIN\|Q17_SPINA_BIFIDA\|Q17_OTHER_CONGEN_MALFO_SPINAL_CORD\|Q17_OTHER_CONGEN_MALFO_NERVOUS_SYSTEM
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	Q0
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	Q0
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

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Similar endpoints

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List of similar endpoints to Congenital malformations of the nervous system based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

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Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	637	431	206
Unadjusted prevalence (%)	0.15	0.19	0.11
Mean age at first event (years)	29.51	30.39	27.69

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.07	3.27 [1.33, 8.03]	9.7e-3	28
15 years	-	-	-	-
5 years	-	-	-	-
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: Q17_CONGEN_MALFO_NERVOUS_SYSTEM – Congenital malformations of the nervous system
GWS hits:

Survival analyses between endpoints

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Plot

before Congenital malformations of the nervous system
after Congenital malformations of the nervous system

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Table

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Drugs most likely to be purchased after Congenital malformations of the nervous system

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Endpoint not on priority list, no data to show.